Which amendment addresses unreasonable search and seizure?

The Fourth Amendment to the United States Constitution specifically addresses the issue of unreasonable search and seizure. It protects citizens from arbitrary governmental invasions into their privacy and property, ensuring that searches and seizures are conducted only when there is probable cause, supported by a warrant issued by a judge. This is a fundamental protection against government overreach, ensuring that individuals' rights to privacy are upheld.

In contrast, the other amendments listed focus on different rights. The First Amendment protects freedoms concerning religion, expression, assembly, and the right to petition the government. The Fifth Amendment safeguards against self-incrimination and assures the right to due process, while the Sixth Amendment guarantees the rights of criminal defendants, including the right to a fair trial and legal counsel. Each amendment has distinct protections, but the Fourth Amendment specifically deals with the issue of searches and seizures, making it the correct choice for this question.